38 research outputs found
Best Practices for Cataloging Streaming Media Using RDA and MARC21
This document is intended to assist catalogers in creating records for streaming media according to instructions within Resource Description and Access (RDA), the successor to the Anglo-American Cataloguing Rules (AACR2)
Best Practices for Cataloging Streaming Media Using RDA and MARC21
This document is intended to assist catalogers in creating records for streaming media according to instructions within Resource Description and Access (RDA), the successor to the Anglo-American Cataloguing Rules (AACR2). Like the original Best Practices for Cataloging Streaming Media, made available in 2008, it covers both streaming video and audio, including those that are born digital, as well as those that are created from an existing resource in another format, such as a video issued on DVD or videocassette. Its main focus is on resources that are “streaming” over the Internet in real-time, rather than resources that are not (e.g., video on CD-ROM or DVD-ROM, MP3 files on compact disc). In addition, it includes some examples of online video and audio files that can be downloaded in their entirety to one’s local computer
Best Practices for Cataloging Streaming Media Using RDA and MARC21 Version 1.1
This document is intended to assist catalogers in creating records for streaming media according to instructions within Resource Description and Access (RDA), the successor to the Anglo-American Cataloguing Rules (AACR2). Like the original Best Practices for Cataloging Streaming Media, made available in 2008, it covers both streaming video and audio, including those that are born digital, as well as those that are created from an existing resource in another format, such as a video issued on DVD or videocassette. Its main focus is on resources that are “streaming” over the Internet in real-time, rather than resources that are not (e.g., video on CD-ROM or DVD-ROM, MP3 files on compact disc). In addition, it includes some examples of online video and audio files that can be downloaded in their entirety to one’s local computer
CMB-S4 Science Book, First Edition
This book lays out the scientific goals to be addressed by the
next-generation ground-based cosmic microwave background experiment, CMB-S4,
envisioned to consist of dedicated telescopes at the South Pole, the high
Chilean Atacama plateau and possibly a northern hemisphere site, all equipped
with new superconducting cameras. CMB-S4 will dramatically advance cosmological
studies by crossing critical thresholds in the search for the B-mode
polarization signature of primordial gravitational waves, in the determination
of the number and masses of the neutrinos, in the search for evidence of new
light relics, in constraining the nature of dark energy, and in testing general
relativity on large scales
Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients
Metastasis continues to be the primary cause of all cancer-related deaths despite the recent advancements in cancer treatments. To evaluate the role of mutations in overall survival (OS) and treatment outcomes, we analyzed 957 metastatic patients with seven major cancer types who had available molecular testing results with a FoundationOne CDx® panel. The most prevalent genes with somatic mutations were TP53, KRAS, APC, and LRP1B. In this analysis, these genes had mutation frequencies higher than in publicly available datasets. We identified that the somatic mutations were seven mutually exclusive gene pairs and an additional fifty-two co-occurring gene pairs. Mutations in the mutually exclusive gene pair APC and CDKN2A showed an opposite effect on the overall survival. However, patients with CDKN2A mutations showed significantly shorter OS (HR: 1.72, 95% CI: 1.34–2.21, p \u3c 0.001) after adjusting for cancer type, age at diagnosis, and sex. Five-year post metastatic diagnosis survival analysis showed a significant improvement in OS (median survival 28 and 43 months in pre-2015 and post-2015 metastatic diagnosis, respectively, p = 0.00021) based on the year of metastatic diagnosis. Although the use of targeted therapies after metastatic diagnosis prolonged OS, the benefit was not statistically significant. However, longer five-year progression-free survival (PFS) was significantly associated with targeted therapy use (median 10.9 months (CI: 9.7–11.9 months) compared to 9.1 months (CI: 8.1–10.1 months) for non-targeted therapy, respectively, p = 0.0029). Our results provide a clinically relevant overview of the complex molecular landscape and survival mechanisms in metastatic solid cancers
CMB-S4: Forecasting Constraints on Primordial Gravitational Waves
CMB-S4---the next-generation ground-based cosmic microwave background (CMB)
experiment---is set to significantly advance the sensitivity of CMB
measurements and enhance our understanding of the origin and evolution of the
Universe, from the highest energies at the dawn of time through the growth of
structure to the present day. Among the science cases pursued with CMB-S4, the
quest for detecting primordial gravitational waves is a central driver of the
experimental design. This work details the development of a forecasting
framework that includes a power-spectrum-based semi-analytic projection tool,
targeted explicitly towards optimizing constraints on the tensor-to-scalar
ratio, , in the presence of Galactic foregrounds and gravitational lensing
of the CMB. This framework is unique in its direct use of information from the
achieved performance of current Stage 2--3 CMB experiments to robustly forecast
the science reach of upcoming CMB-polarization endeavors. The methodology
allows for rapid iteration over experimental configurations and offers a
flexible way to optimize the design of future experiments given a desired
scientific goal. To form a closed-loop process, we couple this semi-analytic
tool with map-based validation studies, which allow for the injection of
additional complexity and verification of our forecasts with several
independent analysis methods. We document multiple rounds of forecasts for
CMB-S4 using this process and the resulting establishment of the current
reference design of the primordial gravitational-wave component of the Stage-4
experiment, optimized to achieve our science goals of detecting primordial
gravitational waves for at greater than , or, in the
absence of a detection, of reaching an upper limit of at CL.Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note:
text overlap with arXiv:1907.0447
CMB-S4 Science Book, First Edition
This book lays out the scientific goals to be addressed by the next-generation ground-based cosmic microwave background experiment, CMB-S4, envisioned to consist of dedicated telescopes at the South Pole, the high Chilean Atacama plateau and possibly a northern hemisphere site, all equipped with new superconducting cameras. CMB-S4 will dramatically advance cosmological studies by crossing critical thresholds in the search for the B-mode polarization signature of primordial gravitational waves, in the determination of the number and masses of the neutrinos, in the search for evidence of new light relics, in constraining the nature of dark energy, and in testing general relativity on large scales
CMB-S4
We describe the stage 4 cosmic microwave background ground-based experiment CMB-S4